The 2005–06 UEFA Cup

Having finished 6th in the 2004-05 season, Sevilla secured a place in the first round of the 2005-06 UEFA Cup. After advancing through the first round and the group stage of competition, Sevilla beat Russian side Lokomotiv Moscow to advance to the round of 16. On 9 March, Sevilla lost 1-0 to French club Lille OSC in the first leg of their home-and-away match, but, on 15 March at home in Sevilla's 50th game in European competition, Sevilla won 2-0 to advance to the quarter-finals. In these matches, which took place against Zenit St. Petersburg on 30 March, and 6 April 2006, Sevilla won 5-2 on aggregate and advanced to the semi-finals.

In the semis, Sevilla knocked out the strong German side Schalke 04 after 180 goalless minutes, with Antonio Puerta scoring the decisive goal in extra time of the return leg. That goal was called by the fans "el gol que nos cambió la vida" - "the goal that changed our lives", because thanks to it, Sevilla played their first European final. On 10 May 2006, in the 2006 UEFA Cup Final, Sevilla broke a 58 year drought on trophies and became the first Andalusian team to win a European final. Sevilla defeated Middlesbrough 4-0 in Eindhoven to win the their first UEFA Cup with the largest margin of victory in a UEFA Cup final. One goal came from Luís Fabiano, two from Enzo Maresca, and one by Frédéric Kanouté. At that time, Sevilla was the only European team which had played in the three major competitions (the European Cup, Cup Winner's Cup and UEFA Cup) and had never lost any game (out of 27) when playing on their home stadium until they lost to AZ on 14 December 2006.

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